TP 003

Tocris Bioscience, part of Bio-Techne | Catalog # 4414

COA / SDS

GABAA partial agonist; acts at benzodiazepine site

Key Product Details

Chemical Name:	2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile
Purity:	≥98%

View Full Technical Details for TP 003

Technical Data
Citations

Biological Activity for TP 003

TP 003 is a GABA_A receptor partial agonist that demonstrates affinity for the benzodiazepine site. Potentiates GABA_A α3 response with high efficacy. Produces anxiolytic-like effects in rodent elevated plus maze via action at GABA_A α2 subtype receptors. Also evokes GABA_A α1 mediated sedation and GABA_A α3 mediated muscle relaxation in mice.

Technical Data for TP 003

Formula	C₂₃H₁₆F₃N₃O
Storage	Store at +4°C
Purity	≥98%
CAS Number	628690-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TP 003

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for TP 003

References are publications that support the biological activity of the product.

Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, Rudolph U, Swinny J Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. , 2014;0(0):. 2014 PMID: 25080596
Dias et al. Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J.Neurosci., 2005;25:10682 PMID: 16291941
Fischer et al. Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys. Psychopharmacology (Berl.), 2011;215:311 PMID: 21190016
Neumann et al. TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA_A receptors. Neuropharmacology, 2018;143:71 PMID: 30240781

TP 003

Tocris Bioscience, part of Bio-Techne | Catalog # 4414

Key Product Details

Biological Activity for TP 003

Technical Data for TP 003

Solubility for TP 003

Dilution Calculator

Reconstitution Calculator

References for TP 003

Product Documents for TP 003

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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