TPMPA

Tocris Bioscience, part of Bio-Techne | Catalog # 1040

(1)

Citations (138)

COA / SDS

Selective GABAA-ρ antagonist

Key Product Details

Description:	Selective GABA_A-ρ antagonist
Chemical Name:	(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid
Purity:	≥97% (HPLC)
Molecular Weight:	161.14

View Full Technical Details for TPMPA

Technical Data
Citations / Reviews (1)

Biological Activity for TPMPA

TPMPA is a selective, competitive GABA_A-ρ antagonist with only minimal effects on GABA_A and GABA_B receptors (K_b values are 2.1 μM (antagonist), 320 μM (antagonist) and EC₅₀ ~ 500 μM (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors.

Technical Data for TPMPA

M. Wt	161.14
Formula	C₆H₁₂NO₂P
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	182485-36-5
PubChem ID	5520
InChi Key	MFUKVPOVVKKLRQ-UHFFFAOYSA-N
Smiles	OP(C1=CCNCC1)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TPMPA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for TPMPA

The following data is based on the product molecular weight 161.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.21 mL	31.03 mL	62.06 mL
5 mM	1.24 mL	6.21 mL	12.41 mL
10 mM	0.62 mL	3.10 mL	6.21 mL
50 mM	0.12 mL	0.62 mL	1.24 mL

Molarity Calculator

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Reconstitution Calculator

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References for TPMPA

References are publications that support the biological activity of the product.

Murata The first selective antagonist for a GABA_c receptor. Bioorg.Med.Chem.Lett.
Ragozzino Design and in vitro pharmacology of a selective γ-aminobutyric acidc receptor antagonist. Mol.Pharmacol. 1996 PMID: 8863850
Xu The involvement of GABA-C receptors in paired pulse depression of inhibitory postsynaptic currents in rat hippocampal CA1 pyramidal neurons. Exp.Neurol. 2009 PMID: 19100735
Chebib GABA_C receptor antagonists differentiate between human r1 and r2 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 1998 PMID: 9797041