Tranilast

Name: Tranilast
Brand: Tocris Bioscience
SKU: 1098

Tocris Bioscience, part of Bio-Techne | Catalog # 1098

Citations (10)

COA / SDS

Antiallergic; inhibits inflammatory mediator release from mast cells

Key Product Details

Description:	Antiallergic; inhibits inflammatory mediator release from mast cells
Chemical Name:	2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	327.34

View Full Technical Details for Tranilast

Technical Data
Citations

Biological Activity for Tranilast

Tranilast is an antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT₁ receptor. Inhibits TRPV2-mediated responses; binds to Aβ40 monomers and increases Aβ40 fibrillation.

Compound Libraries for Tranilast

Tranilast is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Tranilast

M. Wt	327.34
Formula	C₁₈H₁₇NO₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	53902-12-8
PubChem ID	5282230
InChi Key	NZHGWWWHIYHZNX-CSKARUKUSA-N
Smiles	COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tranilast

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.73	100

Preparing Stock Solutions for Tranilast

The following data is based on the product molecular weight 327.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.27 mL	30.55 mL
5 mM	0.61 mL	3.05 mL	6.11 mL
10 mM	0.31 mL	1.53 mL	3.05 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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References for Tranilast

References are publications that support the biological activity of the product.

Connors Tranilast binds to Aβ monomers and promotes Aβ fibrillation. Biochemistry 2013 PMID: 23679559
Hisanaga Regulation of calcium-permeable TRPV2 channel by Ins in pancreatic beta-cells. Diabetes. 2009 PMID: 18984736
Isaji Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br.J.Pharmacol. 1997 PMID: 9401770
Jin Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II. Eur.J.Pharmacol. 1998 PMID: 9865509
Hishikawa Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells. J.Cardiovasc.Pharmacol. 1996 PMID: 8856474