Tranilast

Name: Tranilast
Brand: Tocris Bioscience
SKU: 1098

Tocris Bioscience, part of Bio-Techne | Catalog # 1098

Citations (10)

COA / SDS

Antiallergic; inhibits inflammatory mediator release from mast cells

Key Product Details

Chemical Name:	2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
Purity:	≥99%
Molecular Weight:	327.34 kDa

View Full Technical Details for Tranilast

Technical Data
Citations

Biological Activity for Tranilast

Tranilast is an antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT₁ receptor. Inhibits TRPV2-mediated responses; binds to Aβ40 monomers and increases Aβ40 fibrillation.

Technical Data for Tranilast

M. Wt	327.34 kDa
Formula	C₁₈H₁₇NO₅
Storage	Store at RT
Purity	≥99%
CAS Number	53902-12-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tranilast

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Tranilast

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Isaji et al. Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br.J.Pharmacol., 1997;122:1061 PMID: 9401770
Hishikawa et al. Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells. J.Cardiovasc.Pharmacol., 1996;28:200 PMID: 8856474
Hisanaga et al. Regulation of calcium-permeable TRPV2 channel by Ins in pancreatic beta-cells. Diabetes., 2009;58:174 PMID: 18984736
Jin et al. Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II. Eur.J.Pharmacol., 1998;361:199 PMID: 9865509
Connors et al. Tranilast binds to Aβ monomers and promotes Aβ fibrillation. Biochemistry, 2013; PMID: 23679559