tri-GalNAc-C5-amine

Name: tri-GalNAc-C5-amine
Brand: Tocris Bioscience
SKU: 7781

Tocris Bioscience, part of Bio-Techne | Catalog # 7781

COA / SDS

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

Key Product Details

Description:	Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
Chemical Name:	N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide
Purity:	≥90% (HPLC)
Molecular Weight:	1615.75

View Full Technical Details for tri-GalNAc-C5-amine

Technical Data
Citations

Biological Activity for tri-GalNAc-C5-amine

tri-GalNAc-C5-amine is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with an alkylC5 linker and an amine group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Technical Data for tri-GalNAc-C5-amine

M. Wt	1615.75
Formula	C₆₇H₁₁₈N₁₄O₃₁
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	2098275-86-4
PubChem ID	129115287
InChi Key	WGZBAOGYHCXOAV-WUQQNBSDSA-N
Smiles	CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O)[C@@H]1OCCOCCOCCOCCN(N=N2)C=C2COCC(COCC3=CN(N=N3)CCOCCOCCOCCO[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)(NC(CCCCCN)=O)COCC5=CN(N=N5)CCOCCOCCOCCO[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)CO)O)O)NC(C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for tri-GalNAc-C5-amine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	161.57	100

Preparing Stock Solutions for tri-GalNAc-C5-amine

The following data is based on the product molecular weight 1615.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.62 mL	3.09 mL	6.19 mL
5 mM	0.12 mL	0.62 mL	1.24 mL
10 mM	0.06 mL	0.31 mL	0.62 mL
50 mM	0.01 mL	0.06 mL	0.12 mL

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References for tri-GalNAc-C5-amine

References are publications that support the biological activity of the product.

Sanhueza Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 2017 PMID: 28230359