Trichostatin A

Name: Trichostatin A
Brand: Tocris Bioscience
SKU: 1406

Tocris Bioscience, part of Bio-Techne | Catalog # 1406

(1)

Citations (54)

COA / SDS

Potent histone deacetylase inhibitor

Key Product Details

Chemical Name:	(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Purity:	≥95%
Molecular Weight:	302.37 kDa

View Full Technical Details for Trichostatin A

Technical Data
Citations / Reviews (1)

Biological Activity for Trichostatin A

Trichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (K_i = 3.4 nM, IC₅₀ values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC₅₀ = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington's disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo.Trichostatin A enhances CRISPR-Cas9 gene editing of human induced pluripotent stem cells (iPSCs).

Technical Data for Trichostatin A

M. Wt	302.37 kDa
Formula	C₁₇H₂₂N₂O₃
Storage	Store at -20°C
Purity	≥95%
CAS Number	58880-19-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Trichostatin A

Solubility

Soluble Soluble to 5 mg/ml in DMSO

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References for Trichostatin A

References are publications that support the biological activity of the product.

Serrat N, Pereira-Lopes S, Comalada M, Lloberas J, Celada A Deacetylation of C/EBPbeta is required for IL-4-induced arginase-1 expression in murine macrophages. Eur J Immunol, 0;42(11):3028-37. 0 PMID: 22865229
Galluzzi et al. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov., 2017; PMID: 28529316
Durcova-Hills et al. Reprogramming primordial germ cells into pluripotent stem cells. PloS ONE, 2008;3:e3531 PMID: 18953407
Yoshida et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J.Biol.Chem., 1990;265:17174 PMID: 2211619
Wharton et al. Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A. J.Biol.Chem., 2000;275:33981 PMID: 10945992
Vigushin et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin.Cancer Res., 2001;7:971 PMID: 11309348