Trofinetide

Name: Trofinetide
Brand: Tocris Bioscience
SKU: 7937

Tocris Bioscience, part of Bio-Techne | Catalog # 7937

COA / SDS

IGF-1 synthetic analogue

Key Product Details

Description:	IGF-1 synthetic analogue
Chemical Name:	Glycyl-2-methyl-L-prolyl-L-glutamic acid
Purity:	≥98% (HPLC)
Molecular Weight:	315.32

View Full Technical Details for Trofinetide

Technical Data
Citations

Biological Activity for Trofinetide

Trofinetide is an IGF-1 synthetic analog. It suppresses expression of IL-1β, TNF-α, IFN-γ and E-selectin, and inhibits both acute and delayed neuroinflammation following penetrating ballistic-like brain injury (PBBI) in rats.

Technical Data for Trofinetide

M. Wt	315.32
Formula	C₁₃H₂₁N₃O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	853400-76-7
InChi Key	BUSXWGRAOZQTEY-SDBXPKJASA-N
Smiles	C(N[C@@H](CCC(O)=O)C(O)=O)(=O)[C@@]1(C)N(C(CN)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Trofinetide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.53	100
	DMSO	15.77	50 with gentle warming

Preparing Stock Solutions for Trofinetide

The following data is based on the product molecular weight 315.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.17 mL	15.86 mL	31.71 mL
5 mM	0.63 mL	3.17 mL	6.34 mL
10 mM	0.32 mL	1.59 mL	3.17 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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Reconstitution Calculator

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References for Trofinetide

References are publications that support the biological activity of the product.

Wei NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J.Neuroinflammation 2009 PMID: 19656406