U 46619

Name: U 46619
Brand: Tocris Bioscience
SKU: 1932

Tocris Bioscience, part of Bio-Techne | Catalog # 1932

Citations (151)

COA / SDS

Potent, stable thromboxane A2 (TP) receptor agonist

Key Product Details

Description:	Potent, stable thromboxane A₂ (TP) receptor agonist
Alternative Names:	9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F_2a
Chemical Name:	(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	350.5

View Full Technical Details for U 46619

Technical Data
Citations

Biological Activity for U 46619

U 46619 is a PGH₂ (TXA₂) analog that is a potent and stable thromboxane A₂ (TP) receptor agonist (EC₅₀ = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.

Technical Data for U 46619

M. Wt	350.5
Formula	C₂₁H₃₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	56985-40-1
PubChem ID	5311493
InChi Key	LQANGKSBLPMBTJ-BRSNVKEHSA-N
Smiles	O[C@@H](CCCCC)/C=C/[C@H]1[C@@H]2OC[C@@H](C2)[C@@H]1C/C=C\CCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for U 46619

Solubility

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

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References for U 46619

References are publications that support the biological activity of the product.

Morinelli Receptor-mediated effects of a PGH₂ analogue (U 46619) on human platelets. Am.J.Physiol. 1987 PMID: 3688248
Miggin and Kinsella Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A₂ receptor. Mol.Pharmacol. 2002 PMID: 11901221
Coleman Comparison of the actions of U-46619, a prostaglandin H₂-analogue, with those of prostaglandin H₂ and thromboxane A₂ on some isolated smooth muscle preparations. Br.J.Pharmacol. 1981 PMID: 7248665