U 89843A

Name: U 89843A
Brand: Tocris Bioscience
SKU: 2734

Tocris Bioscience, part of Bio-Techne | Catalog # 2734

COA / SDS

Positive allosteric modulator of GABAA receptors

Discontinued Product

2734 has been discontinued. View all GABA-A Receptor Modulators products.

Key Product Details

Description:	Positive allosteric modulator of GABA_A receptors
Alternative Names:	PNU 89843
Chemical Name:	6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	321.85

View Full Technical Details for U 89843A

Technical Data
Citations

Biological Activity for U 89843A

U 89843A is a positive allosteric modulator of GABA_A receptors. Enhances GABA-induced Cl^- currents in the α₁β₂γ₂, α₃β₂γ₂ and α₆β₂γ₂ subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.

Technical Data for U 89843A

M. Wt	321.85
Formula	C₁₆H₂₃N₅.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	157013-85-9
PubChem ID	56972182
InChi Key	MNKBXPNQWKUSKU-UHFFFAOYSA-N
Smiles	CC2=CC1=C(N3CCCC3)N=C(N4CCCC4)N=C1N2C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for U 89843A

References are publications that support the biological activity of the product.

Haesook U-89843A is a novel allosteric modulator of γ-aminobutyric acid_A receptors. J.Pharmacol.Exp.Ther. 1995 PMID: 8531107
Rohn Inhibition of Ca²⁺-pump ATPase and the Na⁺/K⁺-pump ATPase by iron-generated free radicals. Biochem.Pharmacol. 1996 PMID: 8619892
Bundy Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J.Med.Chem. 1995 PMID: 7473542

U 89843A

Tocris Bioscience, part of Bio-Techne | Catalog # 2734

Key Product Details

Biological Activity for U 89843A

Technical Data for U 89843A

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for U 89843A

Product Documents for U 89843A

COA

Certificate of Analysis

SDS

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