UCPH 101

Name: UCPH 101
Brand: Tocris Bioscience
SKU: 3490

Tocris Bioscience, part of Bio-Techne | Catalog # 3490

Citations (13)

COA / SDS

Selective non-substrate EAAT1 inhibitor

Key Product Details

Description:	Selective non-substrate EAAT1 inhibitor
Chemical Name:	2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	422.48

View Full Technical Details for UCPH 101

Technical Data
Citations

Biological Activity for UCPH 101

UCPH 101 is a selective non-substrate inhibitor of EAAT1 (IC₅₀ values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively). Also demonstrates no significant inhibition at EAAT4 or EAAT5 in a patch-clamp electrophysiology assay (at final concentration up to 10 μM).

Technical Data for UCPH 101

M. Wt	422.48
Formula	C₂₇H₂₂N₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1118460-77-7
PubChem ID	25223366
InChi Key	YBMGNDPBARCLFT-UHFFFAOYSA-N
Smiles	NC2=C(C#N)C(C3=CC=C(OC)C=C3)C1=C(O2)CC(C4=C(C=CC=C5)C5=CC=C4)CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UCPH 101

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.56	25

Preparing Stock Solutions for UCPH 101

The following data is based on the product molecular weight 422.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.47 mL	47.34 mL	94.68 mL
1.25 mM	1.89 mL	9.47 mL	18.94 mL
2.5 mM	0.95 mL	4.73 mL	9.47 mL
12.5 mM	0.19 mL	0.95 mL	1.89 mL

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References for UCPH 101

References are publications that support the biological activity of the product.

Abrahamsen Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J.Neurosci. 2013 PMID: 23325245
Erichsen Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J.Med.Chem. 2010 PMID: 20857912
Bunch Excitatory amino acid transporters as potential drug targets. Exp.Opin.Ther.Targets
Jensen Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J.Med.Chem. 2009 PMID: 19161278