UK 370106

Name: UK 370106
Brand: Tocris Bioscience
SKU: 2900

Tocris Bioscience, part of Bio-Techne | Catalog # 2900

Citations (4)

COA / SDS

Highly selective MMP-3 and MMP-12 inhibitor

Key Product Details

Description:	Highly selective MMP-3 and MMP-12 inhibitor
Chemical Name:	(βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	572.73

View Full Technical Details for UK 370106

Technical Data
Citations

Biological Activity for UK 370106

UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC₅₀ values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC₅₀ = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.

Technical Data for UK 370106

M. Wt	572.73
Formula	C₃₅H₄₄N₂O₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	230961-21-4
PubChem ID	9808181
InChi Key	NSMABJUGSNPHMN-BHYWQNONSA-N
Smiles	CC(C=C(CCC[C@@H](C(N[C@@H]([C@@](C)(C)C)C(N[C@H](COC)C3=CC=CC=C3)=O)=O)CC(O)=O)C=C2)=C2C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UK 370106

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	57.27	100
	ethanol	14.32	25

Preparing Stock Solutions for UK 370106

The following data is based on the product molecular weight 572.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.75 mL	8.73 mL	17.46 mL
5 mM	0.35 mL	1.75 mL	3.49 mL
10 mM	0.17 mL	0.87 mL	1.75 mL
50 mM	0.03 mL	0.17 mL	0.35 mL

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References for UK 370106

References are publications that support the biological activity of the product.

Whitlock A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts.
Matthews Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics
Fray A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 2003 PMID: 12877590