UK 370106

Name: UK 370106
Brand: Tocris Bioscience
SKU: 2900

Tocris Bioscience, part of Bio-Techne | Catalog # 2900

Citations (4)

COA / SDS

Highly selective MMP-3 and MMP-12 inhibitor

Key Product Details

Chemical Name:	(βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid
Purity:	≥95%
Molecular Weight:	572.73 kDa

View Full Technical Details for UK 370106

Technical Data
Citations

Biological Activity for UK 370106

UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC₅₀ values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC₅₀ = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.

Technical Data for UK 370106

M. Wt	572.73 kDa
Formula	C₃₅H₄₄N₂O₅
Storage	Store at -20°C
Purity	≥95%
CAS Number	230961-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UK 370106

Solubility

Soluble Soluble to 100 mM in DMSO and to 25 mM in ethanol

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References for UK 370106

References are publications that support the biological activity of the product.

Fray et al. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem., 2003;46:3514 PMID: 12877590
Whitlock et al. A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts., 2007;17:6750
Matthews et al. Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics, 2008;356:110