UK 78282 hydrochloride

Name: UK 78282 hydrochloride
Brand: Tocris Bioscience
SKU: 3829
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3829

(1)

Citations (1)

COA / SDS

Blocker of KV1.3 and KV1.4 channels

Key Product Details

Description:	Blocker of K_V1.3 and K_V1.4 channels
Chemical Name:	4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	466.05

View Full Technical Details for UK 78282 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for UK 78282 hydrochloride

UK 78282 hydrochloride is a blocker of the K_V1.3 and K_V1.4 voltage-gated potassium channels in T lymphocytes (IC₅₀ values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks K_V1.4 expressed in heart and brain.

Technical Data for UK 78282 hydrochloride

M. Wt	466.05
Formula	C₂₉H₃₅NO₂.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	136647-02-4
PubChem ID	53393337
InChi Key	ZZSQARULZYQMIG-UHFFFAOYSA-N
Smiles	COC(C=C3)=CC=C3CCCN1CCC(COC(C4=CC=CC=C4)C2=CC=CC=C2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UK 78282 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.3	50
	ethanol	13.98	30

Preparing Stock Solutions for UK 78282 hydrochloride

The following data is based on the product molecular weight 466.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.29 mL	21.46 mL	42.91 mL
2.5 mM	0.86 mL	4.29 mL	8.58 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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References for UK 78282 hydrochloride

References are publications that support the biological activity of the product.

Chandy Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 2001 PMID: 11384714
Chandy K⁺ channels as targets for specific immunomodulation. Trends.Pharmacol.Sci. 2004 PMID: 15120495
Hanson UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br.J.Pharmacol. 1999 PMID: 10372812