UNC 0224

Name: UNC 0224
Brand: Tocris Bioscience
SKU: 3861

Tocris Bioscience, part of Bio-Techne | Catalog # 3861

Citations (2)

COA / SDS

Potent G9a and GLP inhibitor

Key Product Details

Description:	Potent G9a and GLP inhibitor
Chemical Name:	7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
Purity:	≥98% (HPLC)
Molecular Weight:	485.67

View Full Technical Details for UNC 0224

Technical Data
Citations

Biological Activity for UNC 0224

UNC 0224 is a potent G9a and GLP inhibitor (IC₅₀ values are 15 and 20 nM in a ThioGlo assay, respectively). Exhibits >1000-fold selectivity for G9a over SET7, SET8 and SET9. UNC 0224 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Technical Data for UNC 0224

M. Wt	485.67
Formula	C₂₆H₄₃N₇O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1197196-48-7
PubChem ID	44251522
InChi Key	XIVUGRBSBIXXJE-UHFFFAOYSA-N
Smiles	CN(CC4)CCC4NC1=C2C(C=C(OCCCN(C)C)C(OC)=C2)=NC(N3CCCN(C)CC3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UNC 0224

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	48.57	100
	DMSO	48.57	100

Preparing Stock Solutions for UNC 0224

The following data is based on the product molecular weight 485.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.30 mL	20.59 mL
5 mM	0.41 mL	2.06 mL	4.12 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for UNC 0224

References are publications that support the biological activity of the product.

Guan Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 2022 PMID: 35418683
Liu Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J.Med.Chem. 2009 PMID: 19891491