UNC 0642

Name: UNC 0642
Brand: Tocris Bioscience
SKU: 5132

Tocris Bioscience, part of Bio-Techne | Catalog # 5132

Citations (10)

COA / SDS

Potent and selective G9a and GLP inhibitor

Key Product Details

Description:	Potent and selective G9a and GLP inhibitor
Chemical Name:	2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Purity:	≥99% (HPLC)
Molecular Weight:	546.7

View Full Technical Details for UNC 0642

Technical Data
Citations

Biological Activity for UNC 0642

UNC 0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC₅₀ < 2.5 nM) that exhibits >2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and >20,000-fold selectivity over other methyltransferases. UNC 0642 reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC₅₀ = 110 nM), and displays modest brain penetration in vivo.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 0642 probe summary on the SGC website.

Compound Libraries for UNC 0642

UNC 0642 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC0642 is reviewed on the chemical probes website.

Technical Data for UNC 0642

M. Wt	546.7
Formula	C₂₉H₄₄F₂N₆O₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1481677-78-4
PubChem ID	53315878
InChi Key	RNAMYOYQYRYFQY-UHFFFAOYSA-N
Smiles	CC(C)N(CC4)CCC4NC1=C2C(C=C(OCCCN3CCCC3)C(OC)=C2)=NC(N5CCC(F)(F)CC5)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UNC 0642

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	54.67	100
	1eq. HCl	27.34	50

Preparing Stock Solutions for UNC 0642

The following data is based on the product molecular weight 546.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.83 mL	9.15 mL	18.29 mL
5 mM	0.37 mL	1.83 mL	3.66 mL
10 mM	0.18 mL	0.91 mL	1.83 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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References for UNC 0642

References are publications that support the biological activity of the product.

Scheer A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 2019 PMID: 30604761
Liu Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J.Med.Chem. 2013 PMID: 24102134