UNC 2327

Name: UNC 2327
Brand: Tocris Bioscience
SKU: 5057

Tocris Bioscience, part of Bio-Techne | Catalog # 5057

COA / SDS

Allosteric inhibitor of PRMT3

Key Product Details

Description:	Allosteric inhibitor of PRMT3
Chemical Name:	N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea
Purity:	≥99% (HPLC)
Molecular Weight:	319.38

View Full Technical Details for UNC 2327

Technical Data
Citations

Biological Activity for UNC 2327

UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC₅₀ = 230 nM). Noncompetitive with both the peptide substrate and cofactor.

Compound Libraries for UNC 2327

UNC 2327 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for UNC 2327

M. Wt	319.38
Formula	C₁₄H₁₇N₅O₂S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1426152-53-5
PubChem ID	71583615
InChi Key	MYTRGTBDVGKKRO-UHFFFAOYSA-N
Smiles	O=C(NCC(N3CCCCC3)=O)NC1=CC=C(N=NS2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UNC 2327

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.94	100

Preparing Stock Solutions for UNC 2327

The following data is based on the product molecular weight 319.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.66 mL	31.31 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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References for UNC 2327

References are publications that support the biological activity of the product.

Liu Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. J.Med.Chem. 2013 PMID: 23445220