UNC 2400

Name: UNC 2400
Brand: Tocris Bioscience
SKU: 4905

Tocris Bioscience, part of Bio-Techne | Catalog # 4905

COA / SDS

Negative control of UNC 1999 (Cat. No. 4904)

Discontinued Product

4905 has been discontinued. View all EZH2 Inhibitor products.

Key Product Details

Description:	Negative control of UNC 1999 (Cat. No. 4904)
Chemical Name:	N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	597.79

View Full Technical Details for UNC 2400

Technical Data
Citations

Biological Activity for UNC 2400

UNC 2400 is a negative control of UNC 1999. Exhibits 1000-fold lower potency than active analog (IC₅₀ values are 62 and >200 μM for EZH1 and EZH2, respectively).

Active Analog also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.

Compound Libraries for UNC 2400

UNC 2400 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for UNC 2400

M. Wt	597.79
Formula	C₃₅H₄₇N₇O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1433200-49-7
PubChem ID	91691116
InChi Key	IFSQHIRDVVFJSQ-UHFFFAOYSA-N
Smiles	CC(C)N1CCN(C2=NC=C(C3=CC(N(C(C)C)N=C4)=C4C(C(N(C)CC5=C(CCC)C=C(C)N(C)C5=O)=O)=C3)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for UNC 2400

References are publications that support the biological activity of the product.

Xu Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood 2015 PMID: 25395428
Konze An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS Chem.Biol. 2013 PMID: 23614352