VAS 2870

Name: VAS 2870
Brand: Tocris Bioscience
SKU: 6654

Tocris Bioscience, part of Bio-Techne | Catalog # 6654

Citations (6)

COA / SDS

NADPH oxidase (Nox) inhibitor

Key Product Details

Chemical Name:	7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
Purity:	≥98%

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Technical Data
Citations

Biological Activity for VAS 2870

VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC₅₀ = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.

Technical Data for VAS 2870

Formula	C₁₈H₁₂N₆OS
Storage	Store at +4°C
Purity	≥98%
CAS Number	722456-31-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VAS 2870

Solubility

Soluble Soluble to 100 mM in DMSO

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References for VAS 2870

References are publications that support the biological activity of the product.

Stielow et al. Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem.Biophys.Res.Commun., 2006;344:200 PMID: 16603125
Sancho and Fabregat et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem.Pharmacol., 2011;81:917 PMID: 21276422
ten Freyhaus et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc.Res., 2006;71:331 PMID: 16545786
Lu et al. VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC Sci.Rep., 2019;9:18852 PMID: 31827142

VAS 2870

Tocris Bioscience, part of Bio-Techne | Catalog # 6654

Key Product Details

Biological Activity for VAS 2870

Technical Data for VAS 2870

Solubility for VAS 2870

Dilution Calculator

Reconstitution Calculator

References for VAS 2870

Product Documents for VAS 2870

COA

Certificate of Analysis

SDS

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