VAS 2870

Name: VAS 2870
Brand: Tocris Bioscience
SKU: 6654

Tocris Bioscience, part of Bio-Techne | Catalog # 6654

Citations (6)

COA / SDS

NADPH oxidase (Nox) inhibitor

Key Product Details

Description:	NADPH oxidase (Nox) inhibitor
Chemical Name:	7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
Purity:	≥98% (HPLC)
Molecular Weight:	360.39

View Full Technical Details for VAS 2870

Technical Data
Citations

Biological Activity for VAS 2870

VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC₅₀ = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.

Compound Libraries for VAS 2870

VAS 2870 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VAS 2870

M. Wt	360.39
Formula	C₁₈H₁₂N₆OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	722456-31-7
PubChem ID	4058452
InChi Key	HZSOKHVVANONPV-UHFFFAOYSA-N
Smiles	N1(N=NC2=C(N=CN=C12)SC3=NC4=CC=CC=C4O3)CC5=CC=CC=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VAS 2870

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.04	100

Preparing Stock Solutions for VAS 2870

The following data is based on the product molecular weight 360.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.75 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for VAS 2870

References are publications that support the biological activity of the product.

Lu VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC Sci.Rep. 2019 PMID: 31827142
Sancho and Fabregat The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem.Pharmacol. 2011 PMID: 21276422
ten Freyhaus Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc.Res. 2006 PMID: 16545786
Stielow Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem.Biophys.Res.Commun. 2006 PMID: 16603125