Vemurafenib

Vemurafenib is a potent inhibitor of BRAF^V600E, C-Raf and wild type B-Raf (IC₅₀ values are 13-31 nM, 6.7-48 nM and 100-160 nM, respectively. Vemurafenib also inhibits SRMS, ACK1 KHS1, FGR (IC₅₀ values are 18 nM, 19 nM, 51 nM and 63 nM, respectively). Vemurafenib shows antitumor activity and induces autophagy in BRAF-mutant thyroid cancer cells.