Verteporfin

Name: Verteporfin
Brand: Tocris Bioscience
SKU: 5305

Tocris Bioscience, part of Bio-Techne | Catalog # 5305

(2)

Citations (48)

COA / SDS

YAP inhibitor

Key Product Details

Chemical Name:	(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
Purity:	≥95%

View Full Technical Details for Verteporfin

Technical Data
Citations / Reviews (2)

Biological Activity for Verteporfin

Verteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC₅₀ = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

Technical Data for Verteporfin

Formula	C₄₁H₄₂N₄O₈
Storage	Store at -20°C
Purity	≥95%
CAS Number	129497-78-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Verteporfin

Solubility

Soluble Soluble to 20 mM in DMSO

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References for Verteporfin

References are publications that support the biological activity of the product.

Song et al. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res., 2014;74:4170 PMID: 24906622
Liu-Chittenden et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev., 2012;26:1300 PMID: 22677547
Brodowska et al. The clinically used photosensitizer vertep. (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res., 2014;124:67 PMID: 24837142

Verteporfin

Tocris Bioscience, part of Bio-Techne | Catalog # 5305

Key Product Details

Biological Activity for Verteporfin

Technical Data for Verteporfin

Solubility for Verteporfin

Dilution Calculator

Reconstitution Calculator

References for Verteporfin

Product Documents for Verteporfin

COA

Certificate of Analysis

SDS

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