Verubecestat

Name: Verubecestat
Brand: Tocris Bioscience
SKU: 7659

Tocris Bioscience, part of Bio-Techne | Catalog # 7659

Citations (1)

COA / SDS

BACE1 and BACE2 inhibitor

Key Product Details

Description:	BACE1 and BACE2 inhibitor
Chemical Name:	N-[3-[(5R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	409.41

View Full Technical Details for Verubecestat

Technical Data
Citations

Biological Activity for Verubecestat

Verubecestat is a high affinity and selective β-secretase 1 (BACE1) and its homolog BACE2 inhibitor (K_i of 2.2 nM and 0.38 nM respectively). It exhibits no inhibition of cathepsin D, cathepsin E, pepsin, or renin. Verubecestat potently reduces Aβ40 formation in HEK293 APP^Swe/Lon cells (IC₅₀ = 2.1 nM). Verubecestat significantly lowers CSF and brain Aβ levels in rats. Orally bioavailable.

Compound Libraries for Verubecestat

Verubecestat is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Verubecestat

M. Wt	409.41
Formula	C₁₇H₁₇F₂N₅O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1286770-55-5
PubChem ID	51352361
InChi Key	YHYKUSGACIYRML-KRWDZBQOSA-N
Smiles	C[C@@]1(C2=CC(NC(=O)C3=CC=C(F)C=N3)=CC=C2F)CS(=O)(=O)N(C)C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Verubecestat

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.94	100
	ethanol	8.19	20

Preparing Stock Solutions for Verubecestat

The following data is based on the product molecular weight 409.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.21 mL	24.43 mL
5 mM	0.49 mL	2.44 mL	4.89 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for Verubecestat

References are publications that support the biological activity of the product.

Scott Discovery of the 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative Verubecestat (MK-8931) - A β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment of Alzheimer's disease. J.Med.Chem. 2016 PMID: 27933948