Vilazodone hydrochloride

Name: Vilazodone hydrochloride
Brand: Tocris Bioscience
SKU: 6202

Tocris Bioscience, part of Bio-Techne | Catalog # 6202

Citations (1)

COA / SDS

Potent 5-HT1A partial agonist and SSRI; antidepressant

Key Product Details

Description:	Potent 5-HT_1A partial agonist and SSRI; antidepressant
Alternative Names:	EMD 68843,SB 659746A
Chemical Name:	5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	477.99

View Full Technical Details for Vilazodone hydrochloride

Technical Data
Citations

Biological Activity for Vilazodone hydrochloride

Vilazodone hydrochloride is a potent 5-HT_1A partial agonist and serotonin-selective reuptake inhibitor (SSRI) (IC₅₀ values are 0.2 and 0.5 nM respectively). Antidepressant.

Compound Libraries for Vilazodone hydrochloride

Vilazodone hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Vilazodone hydrochloride

M. Wt	477.99
Formula	C₂₆H₂₇N₅O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	163521-08-2
PubChem ID	6918313
InChi Key	RPZBRGFNBNQSOP-UHFFFAOYSA-N
Smiles	NC(C1=CC2=C(C=CC(N3CCN(CC3)CCCCC4=CNC5=C4C=C(C#N)C=C5)=C2)O1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vilazodone hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.56	20

Preparing Stock Solutions for Vilazodone hydrochloride

The following data is based on the product molecular weight 477.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.46 mL	52.30 mL	104.60 mL
1 mM	2.09 mL	10.46 mL	20.92 mL
2 mM	1.05 mL	5.23 mL	10.46 mL
10 mM	0.21 mL	1.05 mL	2.09 mL

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Reconstitution Calculator

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References for Vilazodone hydrochloride

References are publications that support the biological activity of the product.

Hughes Neurochemical evaluation of the novel 5-HT_1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. Eur.J.Pharmacol. 2005 PMID: 15740724