Vincristine sulfate

Name: Vincristine sulfate
Brand: Tocris Bioscience
SKU: 1257
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1257

(1)

Citations (18)

COA / SDS

Disrupts microtubules

Key Product Details

Description:	Disrupts microtubules
Chemical Name:	22-Oxovincaleukoblastine
Purity:	≥95% (HPLC)
Molecular Weight:	923.04

View Full Technical Details for Vincristine sulfate

Technical Data
Citations / Reviews (1)

Biological Activity for Vincristine sulfate

Vincristine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.

Technical Data for Vincristine sulfate

M. Wt	923.04
Formula	C₄₆H₅₆N₄O₁₀.H₂SO₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2068-78-2
PubChem ID	249332
InChi Key	AQTQHPDCURKLKT-JKDPCDLQSA-N
Smiles	OS(O)(=O)=O.[H][C@@]23N(C=O)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vincristine sulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for Vincristine sulfate

The following data is based on the product molecular weight 923.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.08 mL	5.42 mL	10.83 mL
5 mM	0.22 mL	1.08 mL	2.17 mL
10 mM	0.11 mL	0.54 mL	1.08 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

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Reconstitution Calculator

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References for Vincristine sulfate

References are publications that support the biological activity of the product.

Takano Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 1993 PMID: 8321748
Wang The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 1999 PMID: 10501907
Jordan Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 PMID: 3986806

Product Documents for Vincristine sulfate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Vincristine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov