VTP 27999 trifluoroacetate

Name: VTP 27999 trifluoroacetate
Brand: Tocris Bioscience
SKU: 5563

Tocris Bioscience, part of Bio-Techne | Catalog # 5563

COA / SDS

Highly potent and selective renin inhibitor

Key Product Details

Description:	Highly potent and selective renin inhibitor
Chemical Name:	Methyl N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamate trifluoroacetate
Purity:	≥97% (HPLC)
Molecular Weight:	639.1

View Full Technical Details for VTP 27999 trifluoroacetate

Technical Data
Citations

Biological Activity for VTP 27999 trifluoroacetate

VTP 27999 trifluoroacetate is a highly potent and selective renin inhibitor (IC₅₀ = 0.47 nM). Displays >1000-fold selectivity over related and unrelated off-targets. Blocks renin-stimulated ERK1/2 phosphorylation in vascular smooth muscle cells. Exhibits a different mode of action to aliskiren (Cat. No. 5491).

Technical Data for VTP 27999 trifluoroacetate

M. Wt	639.1
Formula	C₂₆H₄₁ClN₄O₅.CF₃CO₂H
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1013937-63-7
PubChem ID	121513870
InChi Key	SYWYSVAEGXHOJO-VIEYARBJSA-N
Smiles	ClC1=CC=CC([C@H](OCCNC(OC)=O)[C@]2([H])CCCN(C(NC[C@@H](NC)C[C@H]3CCCOC3)=O)C2)=C1.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VTP 27999 trifluoroacetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	63.91	100
	DMSO	63.91	100

Preparing Stock Solutions for VTP 27999 trifluoroacetate

The following data is based on the product molecular weight 639.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.56 mL	7.82 mL	15.65 mL
5 mM	0.31 mL	1.56 mL	3.13 mL
10 mM	0.16 mL	0.78 mL	1.56 mL
50 mM	0.03 mL	0.16 mL	0.31 mL

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Reconstitution Calculator

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References for VTP 27999 trifluoroacetate

References are publications that support the biological activity of the product.

Lu Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor. J.Hypertens. 2014 PMID: 24637873
Jia Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility. ACS Med.Chem.Lett. 2011 PMID: 24900262