VU 0360172 hydrochloride

Name: VU 0360172 hydrochloride
Brand: Tocris Bioscience
SKU: 4323

Tocris Bioscience, part of Bio-Techne | Catalog # 4323

Citations (2)

COA / SDS

Positive allosteric modulator of mGlu5 receptors

Key Product Details

Description:	Positive allosteric modulator of mGlu₅ receptors
Chemical Name:	N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	330.78

View Full Technical Details for VU 0360172 hydrochloride

Technical Data
Citations

Biological Activity for VU 0360172 hydrochloride

VU 0360172 hydrochloride is a positive allosteric modulator of mGlu₅ receptors (EC₅₀ = 16 nM; K_i = 195 nM). Selective for mGlu₅; displays no significant activity at mGlu₁, mGlu₂ or mGlu₄ receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

Compound Libraries for VU 0360172 hydrochloride

VU 0360172 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 0360172 hydrochloride

M. Wt	330.78
Formula	C₁₈H₁₅FN₂O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1309976-62-2
PubChem ID	53384852
InChi Key	NBGAPTWZQXSEAA-UHFFFAOYSA-N
Smiles	FC1=CC=CC(C#CC2=CC=C(C(NC3CCC3)=O)C=N2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0360172 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.54	50
	ethanol	8.27	25

Preparing Stock Solutions for VU 0360172 hydrochloride

The following data is based on the product molecular weight 330.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.05 mL	30.23 mL	60.46 mL
2.5 mM	1.21 mL	6.05 mL	12.09 mL
5 mM	0.60 mL	3.02 mL	6.05 mL
25 mM	0.12 mL	0.60 mL	1.21 mL

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References for VU 0360172 hydrochloride

References are publications that support the biological activity of the product.

D'Amore Potentiation of mGlu₅ receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. Neuropharmacology 2013 PMID: 22705340
Rodriguez Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 2010 PMID: 20923853