VU 0422288

Name: VU 0422288
Brand: Tocris Bioscience
SKU: 5378

Tocris Bioscience, part of Bio-Techne | Catalog # 5378

COA / SDS

Selective positive allosteric modulator of group III mGlu receptors

Key Product Details

Description:	Selective positive allosteric modulator of group III mGlu receptors
Alternative Names:	ML 396
Chemical Name:	N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	360.19

View Full Technical Details for VU 0422288

Technical Data
Citations

Biological Activity for VU 0422288

VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC₅₀ values are 108, 125 and 146 nM for mGlu₄, mGlu₈ and mGlu₇ respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu₇-mediated reductions in excitatory post synaptic potentials in hippocampal slices.

Technical Data for VU 0422288

M. Wt	360.19
Formula	C₁₇H₁₁Cl₂N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1630936-95-6
PubChem ID	73058507
InChi Key	MZRLPXFGQKQHST-UHFFFAOYSA-N
Smiles	ClC1=CC(NC(C3=CC=CC=N3)=O)=CC=C1OC2=CC=C(Cl)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0422288

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.02	100

Preparing Stock Solutions for VU 0422288

The following data is based on the product molecular weight 360.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.78 mL	13.88 mL	27.76 mL
5 mM	0.56 mL	2.78 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.78 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for VU 0422288

References are publications that support the biological activity of the product.

Jalan-Sakrikar Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem.Neurosci. 2014 PMID: 25225882