VU 0469650 hydrochloride

Name: VU 0469650 hydrochloride
Brand: Tocris Bioscience
SKU: 5379

Tocris Bioscience, part of Bio-Techne | Catalog # 5379

COA / SDS

Potent and selective negative allosteric modulator of mGlu1 receptors

Key Product Details

Description:	Potent and selective negative allosteric modulator of mGlu₁ receptors
Chemical Name:	3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.1^3,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	400.94

View Full Technical Details for VU 0469650 hydrochloride

Technical Data
Citations

Biological Activity for VU 0469650 hydrochloride

VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu₁ (IC₅₀ = 99 nM). Exhibits >100-fold selectivity for mGlu₁ over mGlu_2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.

Technical Data for VU 0469650 hydrochloride

M. Wt	400.94
Formula	C₂₂H₂₈N₄O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1443748-47-7
PubChem ID	71680759
InChi Key	YENVAZRENOYZGQ-GUIQYPADSA-N
Smiles	O=C(N4CCN(C5=C(C#N)N=CC=C5)C[C@H]4C)C12CC(C3)CC(CC3C2)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0469650 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.09	100
	ethanol	20.05	50

Preparing Stock Solutions for VU 0469650 hydrochloride

The following data is based on the product molecular weight 400.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.47 mL	24.94 mL
5 mM	0.50 mL	2.49 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for VU 0469650 hydrochloride

References are publications that support the biological activity of the product.

Lovell N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu₁: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg.Med.Chem.Lett. 2013 PMID: 23727046