VU 0542270

Name: VU 0542270
Brand: Tocris Bioscience
SKU: 8151

Tocris Bioscience, part of Bio-Techne | Catalog # 8151

COA / SDS

Selective inhibitor of Kir6.1 KATP channels

Key Product Details

Description:	Selective inhibitor of K_ir6.1 K_ATP channels
Chemical Name:	1-[(4-Methyl-2-thiophen-2-yl-1,3-thiazol-5-yl)methyl]-3-thiophen-2-ylurea
Purity:	≥98% (HPLC)
Molecular Weight:	335.46

View Full Technical Details for VU 0542270

Technical Data
Citations

Biological Activity for VU 0542270

VU 0542270 is a selective inhibitor of K_ir6.1/SUR2B K_ATP channels (IC₅₀ = 104 nM). Shows no activity at other K_ir channel types at up to 30 μM. Dose-dependently induces constriction of ductus arteriosus vessels.

Technical Data for VU 0542270

M. Wt	335.46
Formula	C₁₄H₁₃N₃OS₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1396814-79-1
PubChem ID	71795439
InChi Key	HMFDAWDOVRPGGW-UHFFFAOYSA-N
Smiles	O=C(NCC1=C(C)N=C(C2=CC=CS2)S1)NC3=CC=CS3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 0542270

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.55	100

Preparing Stock Solutions for VU 0542270

The following data is based on the product molecular weight 335.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.90 mL	29.81 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for VU 0542270

References are publications that support the biological activity of the product.

Li Discovery and characterization of VU0542270, the first selective inhibitor of vascular Kir6.1/SUR2B K_ATP channels. Mol.Pharmacol. 2024 PMID: 38302135