VU 152100

Name: VU 152100
Brand: Tocris Bioscience
SKU: 3383

Tocris Bioscience, part of Bio-Techne | Catalog # 3383

Citations (3)

COA / SDS

Positive allosteric modulator of M4 receptors

Key Product Details

Description:	Positive allosteric modulator of M₄ receptors
Alternative Names:	ML 108
Chemical Name:	3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	341.43

View Full Technical Details for VU 152100

Technical Data
Citations

Biological Activity for VU 152100

VU 152100 is a selective positive allosteric modulator of M₄ muscarinic acetylcholine receptors (mAChRs) (EC₅₀ = 380 nM). Induces 21-fold shift in ACh potency at M₄ receptor. Displays no activity at other mAChR subtypes.

Compound Libraries for VU 152100

VU 152100 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 152100

M. Wt	341.43
Formula	C₁₈H₁₉N₃O₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	409351-28-6
PubChem ID	864492
InChi Key	MDNWGCQSCGNTKH-UHFFFAOYSA-N
Smiles	CC1=C2C(SC(C(NCC3=CC=C(OC)C=C3)=O)=C2N)=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 152100

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.07	50

Preparing Stock Solutions for VU 152100

The following data is based on the product molecular weight 341.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.86 mL	29.29 mL	58.58 mL
2.5 mM	1.17 mL	5.86 mL	11.72 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
25 mM	0.12 mL	0.59 mL	1.17 mL

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References for VU 152100

References are publications that support the biological activity of the product.

Brady Centrally active allosteric potentiators of the M₄ muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 2008 PMID: 18772318