VU 6001966

Name: VU 6001966
Brand: Tocris Bioscience
SKU: 6928

Tocris Bioscience, part of Bio-Techne | Catalog # 6928

Citations (3)

COA / SDS

Potent and selective negative allosteric modulator of mGlu2 receptors

Key Product Details

Description:	Potent and selective negative allosteric modulator of mGlu₂ receptors
Purity:	≥98% (HPLC)
Molecular Weight:	326.33

View Full Technical Details for VU 6001966

Technical Data
Citations

Biological Activity for VU 6001966

VU 6001966 is a potent and selective mGlu₂ negative allosteric modulator (IC₅₀ = 78 nM). Exhibits > 350-fold selectivity for mGlu₂ over mGlu₃. Also exhibits selectivity over other mGluRs and a panel of GPCRs, ion channels and transporters. VU 6001966 induces antidepression like effects in mouse models of chronic stress. CNS penetrant.

Licensing Information

Sold under license from Vanderbilt University

Compound Libraries for VU 6001966

VU 6001966 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 6001966

M. Wt	326.33
Formula	C₁₇H₁₅FN₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2009052-76-8
PubChem ID	122539788
InChi Key	SSSNPJKQBYVHBV-UHFFFAOYSA-N
Smiles	CN1C=CC(COC2=CN=C(C(N)=O)C=C2C3=CC=C(C=C3)F)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 6001966

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.63	100
	ethanol	1.63	5

Preparing Stock Solutions for VU 6001966

The following data is based on the product molecular weight 326.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.06 mL	15.32 mL	30.64 mL
5 mM	0.61 mL	3.06 mL	6.13 mL
10 mM	0.31 mL	1.53 mL	3.06 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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References for VU 6001966

References are publications that support the biological activity of the product.

Joffe mGlu 2 and mGlu 3 negative allosteric modulators divergently enhance thalamocortical transmission and exert rapid antidepressant-like effects. Neuron 2020 PMID: 31735403
Bollinger Design and synthesis of mGlu₂ NAMs with improved potency and CNS penetration based on a truncated picolinamide core. ACS Med.Chem.Lett. 2017 PMID: 28947937