VUF 8430 dihydrobromide

Name: VUF 8430 dihydrobromide
Brand: Tocris Bioscience
SKU: 2494

Tocris Bioscience, part of Bio-Techne | Catalog # 2494

Citations (2)

COA / SDS

Potent and high affinity H4 agonist

Discontinued Product

2494 has been discontinued. View all Histamine H4 Receptor Agonists products.

Key Product Details

Description:	Potent and high affinity H₄ agonist
Chemical Name:	2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide
Molecular Weight:	323.05

View Full Technical Details for VUF 8430 dihydrobromide

Technical Data
Citations

Biological Activity for VUF 8430 dihydrobromide

VUF 8430 dihydrobromide is a high affinity (pK_i = 7.5), potent histamine H₄ receptor full agonist (pEC₅₀ = 7.3). Displays moderate affinity for H₃ receptors (pK_i = 6.0) and weak partial agonist activity at H₂ receptors.

Technical Data for VUF 8430 dihydrobromide

M. Wt	323.05
Formula	C₄H₁₁N₅S.2HBr
Storage	Desiccate at RT
CAS Number	100130-32-3
PubChem ID	3063227
InChi Key	GPWJSTKHQMIXCA-UHFFFAOYSA-N
Smiles	Br.Br.NC(SCCNC(N)=N)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VUF 8430 dihydrobromide

References are publications that support the biological activity of the product.

Lim Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H₄ receptor agonist. J.Med.Chem. 2006 PMID: 17154494
Lim Phenylalanine 169 in the second extracellular loop of the human histamine H₄ receptor is responsible for the difference in agonist binding between human and mouse H₄ receptors. J.Pharmacol.Exp.Ther. 2008 PMID: 18635748
Sterk The influence of guanidio and isothiourea groups in histaminergic compounds on H₂-activity. Agents Actions 1986 PMID: 2942013

VUF 8430 dihydrobromide

Tocris Bioscience, part of Bio-Techne | Catalog # 2494

Key Product Details

Biological Activity for VUF 8430 dihydrobromide

Technical Data for VUF 8430 dihydrobromide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for VUF 8430 dihydrobromide

Product Documents for VUF 8430 dihydrobromide

COA

Certificate of Analysis

SDS

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