WAY 170523

Name: WAY 170523
Brand: Tocris Bioscience
SKU: 2633

Tocris Bioscience, part of Bio-Techne | Catalog # 2633

Citations (9)

COA / SDS

Potent and selective inhibitor of MMP-13

Key Product Details

Description:	Potent and selective inhibitor of MMP-13
Chemical Name:	N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	613.68

View Full Technical Details for WAY 170523

Technical Data
Citations

Biological Activity for WAY 170523

WAY 170523 is a potent and selective inhibitor of MMP-13 (IC₅₀ values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).

Compound Libraries for WAY 170523

WAY 170523 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 170523

M. Wt	613.68
Formula	C₃₃H₃₁N₃O₇S
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	307002-73-9
PubChem ID	9830392
InChi Key	FARMEEAGJWMFSZ-UHFFFAOYSA-N
Smiles	CC1=CC(C(=O)NO)=C(N(CC2=CC=CC=C2)S(=O)(=O)C2=CC=C(OCCNC(=O)C3=CC4=CC=CC=C4O3)C=C2)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 170523

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	61.37	100
	ethanol	61.37	100

Preparing Stock Solutions for WAY 170523

The following data is based on the product molecular weight 613.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.15 mL	16.30 mL
5 mM	0.33 mL	1.63 mL	3.26 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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References for WAY 170523

References are publications that support the biological activity of the product.

Jaffré beta -adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 2012 PMID: 22610965
Chen Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc.