WAY 181187 oxalate

Name: WAY 181187 oxalate
Brand: Tocris Bioscience
SKU: 5589

Tocris Bioscience, part of Bio-Techne | Catalog # 5589

Citations (3)

COA / SDS

High affinity and selective 5-HT6 agonist

Key Product Details

Description:	High affinity and selective 5-HT₆ agonist
Chemical Name:	1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate
Purity:	≥98% (HPLC)
Molecular Weight:	470.91

View Full Technical Details for WAY 181187 oxalate

Technical Data
Citations

Biological Activity for WAY 181187 oxalate

WAY 181187 oxalate is a high affinity and selective 5-HT₆ agonist (K_i = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for WAY 181187 oxalate

WAY 181187 oxalate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 181187 oxalate

M. Wt	470.91
Formula	C₁₅H₁₃ClN₄O₂S₂.C₂H₂O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1883548-85-3
PubChem ID	121513871
InChi Key	KAFVDFYVWBASDD-UHFFFAOYSA-N
Smiles	NCCC2=CN(S(C3=C(Cl)N=C4N3C=CS4)(=O)=O)C1=CC=CC=C12.O=C(O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 181187 oxalate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.09	100

Preparing Stock Solutions for WAY 181187 oxalate

The following data is based on the product molecular weight 470.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.62 mL	21.24 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for WAY 181187 oxalate

References are publications that support the biological activity of the product.

Cole Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT₆ receptor agonist. J.Med.Chem. 2007 PMID: 17948978
Brouard Pharmacological evidence for 5-HT₆ receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 2015 PMID: 25837696