WAY 213613

Name: WAY 213613
Brand: Tocris Bioscience
SKU: 2652
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2652

(1)

Citations (15)

COA / SDS

Potent, non-substrate EAAT2 inhibitor

Key Product Details

Description:	Potent, non-substrate EAAT2 inhibitor
Chemical Name:	N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine
Purity:	≥99% (HPLC)
Molecular Weight:	415.19

View Full Technical Details for WAY 213613

Technical Data
Citations / Reviews (1)

Biological Activity for WAY 213613

WAY 213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC₅₀ values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Another study has found WAY 213613 has 12 - 26-fold selectivity for EAAT2 over EAAT1, EAAT3 and EAAT4 (IC₅₀ values are 0.071, 0.86, 1.5 and 1.9 nM for EAAT2, EAAT1, EAAT4 and EAAT3, respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.

Compound Libraries for WAY 213613

WAY 213613 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 213613

M. Wt	415.19
Formula	C₁₆H₁₃BrF₂N₂O₄
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	868359-05-1
PubChem ID	11531745
InChi Key	BNYDDAAZMBUFRG-ZDUSSCGKSA-N
Smiles	FC1=C(F)C=C(OC2=CC=C(NC(C[C@H](N)C(O)=O)=O)C=C2)C(Br)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 213613

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	41.51	100
	DMSO	41.51	100

Preparing Stock Solutions for WAY 213613

The following data is based on the product molecular weight 415.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.04 mL	24.09 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.20 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for WAY 213613

References are publications that support the biological activity of the product.

Beart and Shea Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br.J.Pharmacol. 2007 PMID: 17088867
Fu Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors. J.Med.Chem. 2018 PMID: 30011368
Dunlop Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol.Pharmacol. 2005 PMID: 16014807