WAY 267464 dihydrochloride

Name: WAY 267464 dihydrochloride
Brand: Tocris Bioscience
SKU: 3933

Tocris Bioscience, part of Bio-Techne | Catalog # 3933

Citations (6)

COA / SDS

Potent non-peptide oxytocin receptor agonist

Key Product Details

Description:	Potent non-peptide oxytocin receptor agonist
Chemical Name:	N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-4-[(3,5-dihydroxyphenyl)methyl]-1-piperazinecarboxamide dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	654.59

View Full Technical Details for WAY 267464 dihydrochloride

Technical Data
Citations

Biological Activity for WAY 267464 dihydrochloride

WAY 267464 dihydrochloride is a potent, selective non-peptide oxytocin receptor (OTR) agonist (K_i = 58.4 nM at human OTR). Exhibits anxiolytic-like effects. May have therapeutic potential for the treatment of psychosis and schizophrenia.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for WAY 267464 dihydrochloride

M. Wt	654.59
Formula	C₃₂H₃₅N₇O₄.2HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1432043-31-6
PubChem ID	71555165
InChi Key	OTFWXMFLPMUDFP-UHFFFAOYSA-N
Smiles	CN(N=C3)C1=C3CN(C(C4=CC=C(CNC(N5CCN(CC6=CC(O)=CC(O)=C6)CC5)=O)C(C)=C4)=O)C(C=CC=C2)=C2N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WAY 267464 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	52.37	80
	water	3.27	5

Preparing Stock Solutions for WAY 267464 dihydrochloride

The following data is based on the product molecular weight 654.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.8 mM	1.91 mL	9.55 mL	19.10 mL
4 mM	0.38 mL	1.91 mL	3.82 mL
8 mM	0.19 mL	0.95 mL	1.91 mL
40 mM	0.04 mL	0.19 mL	0.38 mL

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References for WAY 267464 dihydrochloride

References are publications that support the biological activity of the product.

Ring Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxyt. receptor agonist. Neuropharmacology 2010 PMID: 19615387