WEB 2086

Name: WEB 2086
Brand: Tocris Bioscience
SKU: 2339

Tocris Bioscience, part of Bio-Techne | Catalog # 2339

Citations (30)

COA / SDS

Potent PAF receptor antagonist

Key Product Details

Description:	Potent PAF receptor antagonist
Alternative Names:	Apafant
Chemical Name:	4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
Purity:	≥99% (HPLC)
Molecular Weight:	455.96

View Full Technical Details for WEB 2086

Technical Data
Citations

Biological Activity for WEB 2086

WEB 2086 is a potent, selective platelet-activating factor (PAF) receptor antagonist (K_i = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.

Technical Data for WEB 2086

M. Wt	455.96
Formula	C₂₂H₂₂N₅O₂SCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	105219-56-5
PubChem ID	65889
InChi Key	JGPJQFOROWSRRS-UHFFFAOYSA-N
Smiles	CC1=NN=C2CN=C(C3=C(SC(CCC(=O)N4CCOCC4)=C3)N12)C1=CC=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WEB 2086

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.6	100
	ethanol	45.6	100 with gentle warming

Preparing Stock Solutions for WEB 2086

The following data is based on the product molecular weight 455.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.97 mL	21.93 mL
5 mM	0.44 mL	2.19 mL	4.39 mL
10 mM	0.22 mL	1.10 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for WEB 2086

References are publications that support the biological activity of the product.

Sariahmetoglu Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats. Pharmacol.Res. 1998 PMID: 9782066
Cellai Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. Br.J.Cancer 2006 PMID: 16721373
Dent Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. FEBS Lett. 1989 PMID: 2537761