WIC1

Name: WIC1
Brand: Tocris Bioscience
SKU: 7580

Tocris Bioscience, part of Bio-Techne | Catalog # 7580

COA / SDS

Inhibitor of Wnt/β-catenin signaling

Key Product Details

Description:	Inhibitor of Wnt/β-catenin signaling
Chemical Name:	N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	377.44

View Full Technical Details for WIC1

Technical Data
Citations

Biological Activity for WIC1

WIC1 is an inhibitor of the canonical Wnt/β-catenin signaling pathway. In vitro, it reduces ABSC (Airway Basal Stem Cell) proliferation and induces ciliated epithelial cell differentiation, in a model of squamous lung cancer. WIC1 also represses the phosphorylation of β-catenin^Y489 and Tp63 expression.

Technical Data for WIC1

M. Wt	377.44
Formula	C₂₂H₂₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	943083-58-7
PubChem ID	24746859
InChi Key	YQXKWSNLAVFZJL-UHFFFAOYSA-N
Smiles	CCN1CCN(C2=CC=C(C=C2)NC(C3=CC4=CC=CC=C4OC3=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WIC1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	0.75	2 with gentle warming

Preparing Stock Solutions for WIC1

The following data is based on the product molecular weight 377.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	132.47 mL	662.36 mL	1,324.71 mL
0.1 mM	26.49 mL	132.47 mL	264.94 mL
0.2 mM	13.25 mL	66.24 mL	132.47 mL
1 mM	2.65 mL	13.25 mL	26.49 mL

Molarity Calculator

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Reconstitution Calculator

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References for WIC1

References are publications that support the biological activity of the product.

Aros High-throughput drug screening identifies a potent Wnt inhibitor that promotes airway basal stem cell homeostasis. Cell Rep. 2020 PMID: 32075752