Withaferin A

Name: Withaferin A
Brand: Tocris Bioscience
SKU: 2816

Tocris Bioscience, part of Bio-Techne | Catalog # 2816

(2)

Citations (25)

COA / SDS

Inhibits NF-κB activation

Key Product Details

Chemical Name:	(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone
Purity:	≥98%

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Technical Data
Citations / Reviews (2)

Biological Activity for Withaferin A

Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC₅₀ = 12 nM) and in vivo, prevents NF-κB activation by inhibiting activation of IKKβ and inhibits chymotrypsin-like activity of the 20S proteasome. In an animal model of Huntington's disease (HD), Withaferin A delays disease progression and increases lifespan; in a cellular model it suppresses aggregation of mutant huntingtin, activates HSF1 and induces Hsp70 chaperone expression.

Technical Data for Withaferin A

Formula	C₂₈H₃₈O₆
Storage	Store at -20°C
Purity	≥98%
CAS Number	5119-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Withaferin A

Solubility

Soluble Soluble to 10 mM in DMSO

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References for Withaferin A

References are publications that support the biological activity of the product.

Mohan et al. Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis, 2004;7:115 PMID: 15516832
Yang et al. The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian Winter Cherry". Mol.Pharmacol., 2007;71:426 PMID: 17093135
Kaileh et al. Withaferin A strongly elicits IkB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity. J.Biol.Chem., 2007;282:4253 PMID: 17150968

Withaferin A

Tocris Bioscience, part of Bio-Techne | Catalog # 2816

Key Product Details

Biological Activity for Withaferin A

Technical Data for Withaferin A

Solubility for Withaferin A

Dilution Calculator

Reconstitution Calculator

References for Withaferin A

Product Documents for Withaferin A

COA

Certificate of Analysis

SDS

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