WQ 1

Name: WQ 1
Brand: Tocris Bioscience
SKU: 7156

Tocris Bioscience, part of Bio-Techne | Catalog # 7156

Citations (1)

COA / SDS

Potent and selective σ1 receptor antagonist; active in vivo

Key Product Details

Description:	Potent and selective σ1 receptor antagonist; active in vivo
Alternative Names:	TC WQ 1,TC Sigma1
Chemical Name:	2,3-Dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-benzothiopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	337.48

View Full Technical Details for WQ 1

Technical Data
Citations

Biological Activity for WQ 1

WQ 1 is a high affinity and selective σ1 receptor antagonist (pK_i values are 10.28-10.85, 5.81-6.53 and 5.80 at σ1, σ2 and DAT). Displays σ1/σ2 selectivity ratio of 29512. Selectively blocks binge eating without a general inhibition of food intake in rats.

Compound Libraries for WQ 1

WQ 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WQ 1

M. Wt	337.48
Formula	C₂₁H₂₃NOS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1204401-49-9
InChi Key	XWMHOCDNGHEUMF-UHFFFAOYSA-N
Smiles	O=C(C1=CC=CC=C1S2)CC2C3CCN(CC4=CC=CC=C4)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WQ 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	16.87	50
	ethanol	3.37	10

Preparing Stock Solutions for WQ 1

The following data is based on the product molecular weight 337.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.93 mL	29.63 mL	59.26 mL
2.5 mM	1.19 mL	5.93 mL	11.85 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
25 mM	0.12 mL	0.59 mL	1.19 mL

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References for WQ 1

References are publications that support the biological activity of the product.

Piergentili Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J.Med.Chem. 2010 PMID: 20067271
Bello Investigation of the role of chirality in the interaction with σ receptors and effect on binge eating episode of a potent σ 1 antagonist analogue of spipethiane. ACS Chem.Neurosci. 2019 PMID: 31298830