WR 1065 dihydrochloride

Name: WR 1065 dihydrochloride
Brand: Tocris Bioscience
SKU: 3356

Tocris Bioscience, part of Bio-Techne | Catalog # 3356

Citations (2)

COA / SDS

p53 activator. Also ROS scavenger

Key Product Details

Description:	p53 activator. Also ROS scavenger
Chemical Name:	2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride
Molecular Weight:	207.16

View Full Technical Details for WR 1065 dihydrochloride

Technical Data
Citations

Biological Activity for WR 1065 dihydrochloride

WR 1065 dihydrochloride is a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21^waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.

Technical Data for WR 1065 dihydrochloride

M. Wt	207.16
Formula	C₅H₁₄N₂S.2HCl
Storage	Desiccate at -20°C
CAS Number	14653-77-1
PubChem ID	146169
InChi Key	XDRLRDHLCIFZIW-UHFFFAOYSA-N
Smiles	NCCCNCCS.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WR 1065 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.72	100
	DMSO	20.72	100

Preparing Stock Solutions for WR 1065 dihydrochloride

The following data is based on the product molecular weight 207.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.83 mL	24.14 mL	48.27 mL
5 mM	0.97 mL	4.83 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.83 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

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References for WR 1065 dihydrochloride

References are publications that support the biological activity of the product.

Pluquet The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J.Biol.Chem. 2003 PMID: 12531896
Walker WR1065 mitigates AZT-ddl-induced mutagenesis and inhibits viral replication. Enviorn.Mol.Mutagen.
North The cytoprotective aminothiol WR1065 activates p21^waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene 2000 PMID: 10713709