WRW4

Tocris Bioscience, part of Bio-Techne | Catalog # 2262

(1)

Citations (70)

COA / SDS

Selective FPR2 antagonist

Key Product Details

Description:	Selective FPR2 antagonist
Alternative Names:	WRW⁴
Purity:	≥95% (HPLC)
Molecular Weight:	1104.28

View Full Technical Details for WRW4

Technical Data
Citations / Reviews (1)

Biological Activity for WRW4

WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC₅₀ = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

Technical Data for WRW4

M. Wt	1104.28
Formula	C₆₁H₆₅N₁₅O₆
Single Letter Sequence	WRWWWW (Modification: Trp-6 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	878557-55-2
PubChem ID	49768327
InChi Key	IRJDOVLLPORVJP-WOAIKHIASA-N
Smiles	[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WRW4

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for WRW4

References are publications that support the biological activity of the product.

Bae Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 2004 PMID: 15210823