WS 12

Name: WS 12
Brand: Tocris Bioscience
SKU: 3040
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3040

(2)

Citations (23)

COA / SDS

TRPM8 agonist; cooling agent

Key Product Details

Description:	TRPM8 agonist; cooling agent
Chemical Name:	(1R,2S)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	289.41

View Full Technical Details for WS 12

Technical Data
Citations / Reviews (2)

Biological Activity for WS 12

WS 12 is a potent TRPM8 agonist that acts as a cooling agent (EC₅₀ = 193 nM).

Technical Data for WS 12

M. Wt	289.41
Formula	C₁₈H₂₇NO₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	68489-09-8
PubChem ID	11266244
InChi Key	HNSGVPAAXJJOPQ-XOKHGSTOSA-N
Smiles	C[C@H](C)[C@H]1[C@H]([C@@](NC2=CC=C(OC)C=C2)=O)C[C@H](C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WS 12

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	21.71	75

Preparing Stock Solutions for WS 12

The following data is based on the product molecular weight 289.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.61 mL	23.04 mL	46.07 mL
3.75 mM	0.92 mL	4.61 mL	9.21 mL
7.5 mM	0.46 mL	2.30 mL	4.61 mL
37.5 mM	0.09 mL	0.46 mL	0.92 mL

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Reconstitution Calculator

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References for WS 12

References are publications that support the biological activity of the product.

Bodding Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 2007 PMID: 17517434
Beck Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 2007 PMID: 16949669