WYE 687 dihydrochloride

Name: WYE 687 dihydrochloride
Brand: Tocris Bioscience
SKU: 4282

Tocris Bioscience, part of Bio-Techne | Catalog # 4282

Citations (3)

COA / SDS

Potent and selective mTOR inhibitor

Key Product Details

Description:	Potent and selective mTOR inhibitor
Chemical Name:	N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	601.53

View Full Technical Details for WYE 687 dihydrochloride

Technical Data
Citations

Biological Activity for WYE 687 dihydrochloride

WYE 687 dihydrochloride is a potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC₅₀ = 7 nM). Displays selectivity for mTOR over PI 3-Kα (~100-fold) and PI 3-Kγ (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1α expression. Exhibits antiproliferative effects in cancer cell lines through G₁ cell cycle arrest and selective apoptosis.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for WYE 687 dihydrochloride

WYE 687 dihydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for WYE 687 dihydrochloride

M. Wt	601.53
Formula	C₂₈H₃₂N₈O₃2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1702364-87-1
PubChem ID	90488926
InChi Key	ZQJPHAXLAKKXIX-UHFFFAOYSA-N
Smiles	O=C(OC)NC(C=C4)=CC=C4C1=NC(N3CCOCC3)=C2C(N(C5CCN(CC6=CN=CC=C6)CC5)N=C2)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WYE 687 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	60.15	100
	DMSO	60.15	100

Preparing Stock Solutions for WYE 687 dihydrochloride

The following data is based on the product molecular weight 601.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.31 mL	16.62 mL
5 mM	0.33 mL	1.66 mL	3.32 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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References for WYE 687 dihydrochloride

References are publications that support the biological activity of the product.

Yu Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer.Res. 2009 PMID: 19584280