Xanthohumol

Name: Xanthohumol
Brand: Tocris Bioscience
SKU: 4686

Tocris Bioscience, part of Bio-Techne | Catalog # 4686

Citations (4)

COA / SDS

p97 ATPase (VCP) inhibitor

Key Product Details

Description:	p97 ATPase (VCP) inhibitor
Chemical Name:	(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	354.4

View Full Technical Details for Xanthohumol

Technical Data
Citations

Biological Activity for Xanthohumol

Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC₅₀ = 50.3 μM).

Compound Libraries for Xanthohumol

Xanthohumol is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Xanthohumol

M. Wt	354.4
Formula	C₂₁H₂₂O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	6754-58-1
PubChem ID	639665
InChi Key	ORXQGKIUCDPEAJ-YRNVUSSQSA-N
Smiles	OC1=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=CC(O)=C1C/C=C(C)/C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Xanthohumol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.44	100
	ethanol	35.44	100

Preparing Stock Solutions for Xanthohumol

The following data is based on the product molecular weight 354.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.11 mL	28.22 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for Xanthohumol

References are publications that support the biological activity of the product.

Tabata Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 1997 PMID: 9366096
Inokoshi Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo) 2009 PMID: 19132064
Sasazawa Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol. 2012 PMID: 22360440