XE 991 dihydrochloride

Name: XE 991 dihydrochloride
Brand: Tocris Bioscience
SKU: 2000

Tocris Bioscience, part of Bio-Techne | Catalog # 2000

(1)

Citations (844)

COA / SDS

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents

Key Product Details

Chemical Name:	10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
Purity:	≥99%
Molecular Weight:	449.37 kDa

View Full Technical Details for XE 991 dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for XE 991 dihydrochloride

XE 991 dihydrochloride is a potent and selective blocker of K_V7 (KCNQ) voltage-gated potassium channels. Blocks K_V7.2+7.3 (KCNQ2+3) / M-currents (IC₅₀ = 0.6 - 0.98 μM) and K_V7.1 (KCNQ1) homomeric channels (IC₅₀ = 0.75 μM) but is less potent against K_V7.1/minK channels (IC₅₀ = 11.1 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Technical Data for XE 991 dihydrochloride

M. Wt	449.37 kDa
Formula	C₂₆H₂₀N₂O.2HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	122955-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XE 991 dihydrochloride

Solubility

Soluble Soluble to 100 mM in water

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References for XE 991 dihydrochloride

References are publications that support the biological activity of the product.

Wang et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science, 1998;282:1890 PMID: 9836639
Zaczek et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther., 1998;285:724 PMID: 9580619
Wang et al. Molecular basis for differential sensitivity of KCNQ and I_Ks channels to the cognitive enhancer XE991. Mol.Pharmacol., 2000;57:1218 PMID: 10825393
Passmore et al. KCNQ/M currents in sensory neurons: significance for pain therapy. J.Neurosci., 2003;23:7227 PMID: 12904483