Y 134

Name: Y 134
Brand: Tocris Bioscience
SKU: 2676

Tocris Bioscience, part of Bio-Techne | Catalog # 2676

Citations (6)

COA / SDS

Selective estrogen receptor modulator (SERM), selective for ERα

Key Product Details

Description:	Selective estrogen receptor modulator (SERM), selective for ERα
Chemical Name:	[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	472.6

View Full Technical Details for Y 134

Technical Data
Citations

Biological Activity for Y 134

Y 134 is a selective estrogen receptor modulator (SERM) that displays selectivity for ERα over ERβ (K_i values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.

Technical Data for Y 134

M. Wt	472.6
Formula	C₂₈H₂₈N₂O₃S
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	849662-80-2
PubChem ID	11784736
InChi Key	LQEOPHGPHCWOAC-UHFFFAOYSA-N
Smiles	CC(C)N1CCN(CC1)C1=CC=C(C=C1)C(=O)C1=C(SC2=CC(O)=CC=C12)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Y 134

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.26	100
	ethanol	47.26	100

Preparing Stock Solutions for Y 134

The following data is based on the product molecular weight 472.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.58 mL	21.16 mL
5 mM	0.42 mL	2.12 mL	4.23 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for Y 134

References are publications that support the biological activity of the product.

Ning Biological activities of a novel selective oestrogen receptor modulator derived from ralox. (Y134). Br.J.Pharmacol. 2007 PMID: 17115070
Yang Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo. Bioorg.Med.Chem.Lett. 2005 PMID: 15713417