Y-27632 in solution

Name: Y-27632 in solution
Brand: Tocris Bioscience
SKU: 7000

Tocris Bioscience, part of Bio-Techne | Catalog # 7000

COA / SDS

Sterile-filtered 10 mM solution of Y-27632 pre-dissolved in water

Key Product Details

Description:	Sterile-filtered 10 mM solution of Y-27632 pre-dissolved in water
Chemical Name:	trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	320.26

View Full Technical Details for Y-27632 in solution

Technical Data
Citations

Biological Activity for Y-27632 in solution

Y-27632 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of Y-27632 (Cat. No. 1254), pre-dissolved in water. Increases survival rate of human embryonic stem (hES) cells and iPSC undergoing cryopreservation. Optimizes naive human pluripotent stem cell growth and viability following naive cell derivation from primed ESCs and iPSCs using naive human stem cell medium (NHSM). Used as a component of growth media for urothelial organoids and in a protocol to generate brain organoids from human iPSCs.

Supplied in vials containing a minimum of 1 mL of Y-27632 solution.

Technical Data for Y-27632 in solution

M. Wt	320.26
Formula	C₁₄H₂₁N₃O.2HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	129830-38-2
PubChem ID	9901617
InChi Key	IDDDVXIUIXWAGJ-LJDSMOQUSA-N
Smiles	N[C@H](C)[C@@]1([H])CC[C@H](C(NC2=CC=NC=C2)=O)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Y-27632 in solution

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References for Y-27632 in solution

References are publications that support the biological activity of the product.

Wilson Cryopreservation of brain endothelial cells derived from human induced pluripotent stem cells is enhanced by Rho-associated coiled coil-containing kinase inhibition. Tissue.Eng.Part C.Methods 2016 PMID: 27846787
Ichikawa Freeze-thawing single human embryonic stem cells induce e-cadherin and actin filament network disruption via g13 signaling. Cryo Letters 2011 PMID: 22227712
Schafer An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell 2023 PMID: 37172564