YIL 781 hydrochloride

Name: YIL 781 hydrochloride
Brand: Tocris Bioscience
SKU: 3959

Tocris Bioscience, part of Bio-Techne | Catalog # 3959

Citations (4)

COA / SDS

Ghrelin receptor (GHS-R1a) antagonist

Key Product Details

Description:	Ghrelin receptor (GHS-R1a) antagonist
Chemical Name:	6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	445.96

View Full Technical Details for YIL 781 hydrochloride

Technical Data
Citations

Biological Activity for YIL 781 hydrochloride

YIL 781 hydrochloride is a ghrelin receptor antagonist (GHS-R1a) (K_i = 17 nM). Displays no significant affinity for the motilin receptor (K_i = 6 μM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo.

Compound Libraries for YIL 781 hydrochloride

YIL 781 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YIL 781 hydrochloride

M. Wt	445.96
Formula	C₂₄H₂₈FN₃O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1640226-17-0
PubChem ID	74889155
InChi Key	QQGRMONBDBMLSP-FERBBOLQSA-N
Smiles	O=C2C1=CC(OC4=CC=C(F)C=C4)=CC=C1N=C(C)N2C[C@@H]3CN(C(C)C)CCC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YIL 781 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.6	100
	water	44.6	100

Preparing Stock Solutions for YIL 781 hydrochloride

The following data is based on the product molecular weight 445.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.21 mL	22.42 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for YIL 781 hydrochloride

References are publications that support the biological activity of the product.

Moran and Dailey Gut peptides: targets for antiobesity drug development? Endocrinology 2009 PMID: 19372201
Esler Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 2007 PMID: 17656463