YM 022

Tocris Bioscience, part of Bio-Techne | Catalog # 1408

COA / SDS

Highly potent, selective non-peptide CCK2 antagonist

Key Product Details

Description:	Highly potent, selective non-peptide CCK₂ antagonist
Chemical Name:	(R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea
Purity:	≥99% (HPLC)
Molecular Weight:	516.6

View Full Technical Details for YM 022

Technical Data
Citations

Biological Activity for YM 022

YM 022 is an extremely potent and highly selective non-peptide CCK₂ silent antagonist (K_i values are 68 pM and 63 nM at CCK₂ and CCK₁ receptors respectively). Acts in vivo to potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with a long duration of action.

Technical Data for YM 022

M. Wt	516.6
Formula	C₃₂H₂₈N₄O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	145084-28-2
PubChem ID	3452843
InChi Key	YCXFHPUBGMMWJQ-UHFFFAOYSA-N
Smiles	CC1=CC(NC(=O)NC2N=C(C3=CC=CC=C3)C3=CC=CC=C3N(CC(=O)C3=C(C)C=CC=C3)C2=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 022

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.66	100
	ethanol	5.17	10

Preparing Stock Solutions for YM 022

The following data is based on the product molecular weight 516.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.68 mL	19.36 mL
5 mM	0.39 mL	1.94 mL	3.87 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for YM 022

References are publications that support the biological activity of the product.

Kitano Long-lasting cholecystokinin₂ receptor blockade after a single subcutaneous injection of YF476 or YM022. Br.J.Pharmacol. 2000 PMID: 10821801
Nishida Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro J.Pharmacol.Exp.Ther. 1994 PMID: 7910212
Beinborn Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones. Yale J.Biol.Med. 1998 PMID: 10461364