YM 155

Name: YM 155
Brand: Tocris Bioscience
SKU: 6491

Tocris Bioscience, part of Bio-Techne | Catalog # 6491

Citations (6)

COA / SDS

Survivin suppressor

Key Product Details

Chemical Name:	4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for YM 155

YM 155 is a survivin suppressor. Down-regulates survivin expression and sensitizes human NSCLC cell lines to radiation. Enhances radiation-induced tumor regression in nude mice bearing NSCLC xenografts. Also induces apoptosis in TRAIL-resistant glioma cells in vitro. YM 155 is also an inhibitor of ILF3 (interleukin enhancer binding factor 3), an RNA-binding protein. It reduces thermal and mechanical hypersensitivity in a mice model of inflammatory pain.

Technical Data for YM 155

Formula	C₂₀H₁₉BrN₄O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	781661-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 155

Solubility

Soluble Soluble to 100 mM in water and to 20 mM in DMSO

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References for YM 155

References are publications that support the biological activity of the product.

Iwasa et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin.Cancer Res., 2008;14:6496 PMID: 18927289
Premkumar et al. Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway. J.Pharmacol.Exp.Ther., 2013;346:201 PMID: 23740602

YM 155

Tocris Bioscience, part of Bio-Techne | Catalog # 6491

Key Product Details

Biological Activity for YM 155

Technical Data for YM 155

Solubility for YM 155

Dilution Calculator

Reconstitution Calculator

References for YM 155

Product Documents for YM 155

COA

Certificate of Analysis

SDS

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