YM 202074 sesquifumarate

Name: YM 202074 sesquifumarate
Brand: Tocris Bioscience
SKU: 3413

Tocris Bioscience, part of Bio-Techne | Catalog # 3413

COA / SDS

High affinity, selective mGlu1 antagonist

Discontinued Product

3413 has been discontinued. View all Group I mGluR Antagonists products.

Key Product Details

Description:	High affinity, selective mGlu₁ antagonist
Chemical Name:	N-Cyclohexyl-6-[[N-(2-methoxyethyl)-N-methylamino]methyl]-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide sesquifumarate
Purity:	≥99% (HPLC)
Molecular Weight:	588.67

View Full Technical Details for YM 202074 sesquifumarate

Technical Data
Citations

Biological Activity for YM 202074 sesquifumarate

YM 202074 sesquifumarate is a high affinity, selective metabotropic glutamate receptor type 1 (mGlu₁) antagonist. Binds an allosteric site of the rat mGlu₁ receptor with a K_i of 4.8 nM. Inhibits mGlu₁-mediated inositol phosphates production (IC₅₀ = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo.

Technical Data for YM 202074 sesquifumarate

M. Wt	588.67
Formula	C₂₂H₃₀N₄O₂S.1.5C₄H₄O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	299900-84-8
PubChem ID	90488842
InChi Key	HABHEZNVNBKOQJ-VQYXCCSOSA-N
Smiles	CN(CCOC)CC1=CC=C2C(N(C=C(C(N(C)C4CCCCC4)=O)S3)C3=N2)=C1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O.CN(CCOC)CC5=CC=C6C(N(C=C(C(N(C)C8CCCCC8)=O)S7)C7=N6)=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for YM 202074 sesquifumarate

References are publications that support the biological activity of the product.

Ferraguti Metabotropic glutamate 1 receptor: current concepts and perspectives. Pharmacol.Rev. 2008 PMID: 19112153
Yanamoto Radiosynthesis and evaluation of [¹¹C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1. Nucl.Med.Biol. 2010 PMID: 20610166
Kohara Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models. Brain Res. 2008 PMID: 18164695

YM 202074 sesquifumarate

Tocris Bioscience, part of Bio-Techne | Catalog # 3413

Key Product Details

Biological Activity for YM 202074 sesquifumarate

Technical Data for YM 202074 sesquifumarate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for YM 202074 sesquifumarate

Product Documents for YM 202074 sesquifumarate

COA

Certificate of Analysis

SDS

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