YM 244769

Name: YM 244769
Brand: Tocris Bioscience
SKU: 4544

Tocris Bioscience, part of Bio-Techne | Catalog # 4544

Citations (12)

COA / SDS

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

Key Product Details

Chemical Name:	N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
Purity:	≥99%

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Technical Data
Citations

Biological Activity for YM 244769

YM 244769 is an inhibitor of the reverse mode of Na⁺/Ca²⁺ exchange (NCX). Potently inhibits Na⁺-dependent ⁴⁵Ca²⁺ uptake (IC₅₀ values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na⁺ and Ca²⁺ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Technical Data for YM 244769

Formula	C₂₆H₂₂FN₃O₃.2HCl
Storage	Desiccate at RT
Purity	≥99%
CAS Number	1780390-65-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 244769

Solubility

Soluble Soluble to 100 mM in DMSO

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References for YM 244769

References are publications that support the biological activity of the product.

Iwamoto et al. Na⁺/Ca²⁺ exchange inhibitors: a new class of calcium regulators. Cardiovasc.Hematol.Disord.Drug Targets, 2007;7:188 PMID: 17896959
Iwamoto and Kita YM-244769, a novel Na⁺/Ca²⁺ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol.Pharmacol., 2006;70:2075 PMID: 16973719

YM 244769

Tocris Bioscience, part of Bio-Techne | Catalog # 4544

Key Product Details

Biological Activity for YM 244769

Technical Data for YM 244769

Solubility for YM 244769

Dilution Calculator

Reconstitution Calculator

References for YM 244769

Product Documents for YM 244769

COA

Certificate of Analysis

SDS

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